Asish Banerjee has maintained a prominent role within the Trinamool Congress (TMC) party in West Bengal. His professional background began in the education sector, where he worked as a teacher before transitioning into full-time politics. Over the course of his career, he has become a key figure within the state administration.

During his tenure in the government led by Chief Minister Mamata Banerjee, Asish Banerjee held several ministerial portfolios. These responsibilities included overseeing the AYUSH department, which focuses on traditional medicine, as well as the agriculture department. Beyond his ministerial duties, he has functioned as an aide to the Chief Minister, playing a role in the party's internal operations and governance strategy. While his career is characterized by these administrative roles, the scope of his influence and specific policy achievements remain subjects of broader political discussion within the state.